DL Phenylalanine

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DL Phenylalanine Depression


One of the most recurrent psychological problems encountered in medical practice is depression. A study published in July 1996 in "Postgraduate Medicine" demonstrated that around two-thirds of depressed patients may by no means be given suitable intervention. If you are in torment from depression, antidepressant medications can work healthy for you. But every antidepressant has its own side effects. Taking D-phenylalanine supplements can in a lot of cases be utilized as a substitute to antidepressant drugs in the management of your depression. Seek advice from your doctor prior to taking a phenylalanine supplement for depression.

About Phenylalanine
Phenylalanine transpires in three chemical forms: L-phenylalanine, D-phenylalanine and Dl-phenylalanine; this last embraces a mixture of D and L forms of phenylalanine. D-phenylalanine is a non-nutrient amino acid manufactured in the laboratory. In your body, phenylalanine is transformed into another amino acid termed as tyrosine, which sequentially is converted into three brain chemicals named l-dopa, epinephrine and norepinephrine. In accordance with the University of Maryland Medical Center, a variety of forms of phenylalanine have been employed for the management of depression in view of the fact that antidepressants moreover work by raising the level of epinephrine in the body.

Clinical Evidence
The NYU Langone Medical Center accounts the result of a duo of double-blind relative studies that established that D-phenylalanine at a day by day dosage of 100 mg may be as efficient as imipramine, an antidepressant drug. The research embraced 60 individuals with gentle to moderate depression. As said by researchers, people with depression taking D-phenylalanine demonstrated noteworthy development in barely 15 days as compared to imipramine, which required more than a few weeks to take effect.

A good number of the scientific studies focusing on the benefits of phenylalanine on depression were performed in the 1970s and 1980s. One study printed in 1977 in the "Journal of Neural Transmission" confirmed the benefits of DL-phenylalanine for easing depression in the majority of the study participants. On the other hand, one more study published in the December 1980 issue of the "American Journal of Psychiatry" investigated the effects of D-phenylalanine on patients anguishing from a form of atypical depression called as endogenous depression. In this research, no antidepressant benefits were connected with D-phenylalanine, even though additional research using elevated prescribed amounts was suggested. An investigation published in 1979 in the "European Archives of Psychiatry and Neuroscience" evaluated the effects of DL-phenylalanine and the tricyclic antidepressant medication imipramine. The analysis confirmed that DL-phenylalanine may have antidepressant effects, while more research was suggested.

Interaction
People with depression ingesting monoamine oxidase inhibitors, an adult rank of antidepressants, ought to keep away from supplements containing phenylalanine, in relation to the University of Maryland Medical Center. If you take phenylalanine in amalgamation with monoamine oxidase inhibitors you risk a boost in blood pressure that could make possible a heart attack.

Safety Issues
In accordance with the NYU Langone Medical Center, D-phenylalanine supplements must be avoided by individuals with phenylketonuria, a genetic disorder that is distinguished by an incapability of the body to appropriately break down phenylalanine. Work intimately with your doctor prior to taking phenylalanine as a higher than suggested prescribed amount may cause side effects such as nausea, headaches and heartburn.